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After administering losartan, a client presents with a hoarse voice and swollen lips. What should be the nurse's first action?

  1. Assess the client's airway

  2. Administer IV antihistamines

  3. Apply high flow oxygen

  4. Initiate IV access

The correct answer is: Assess the client's airway

The first action a nurse should take when a client presents with a hoarse voice and swollen lips after administering losartan is to assess the client's airway. This is because these symptoms can indicate a potentially life-threatening allergic reaction, known as anaphylaxis, which can cause severe swelling of the airway and compromise breathing. Option B (administer IV antihistamines) and C (apply high flow oxygen) are incorrect because they do not address the priority of ensuring a patent airway. Option D (initiate IV access) may be necessary for treatment, but it is not the first action that should be taken in this emergency situation. Therefore, option A is the most appropriate and urgent action for the nurse to take.